Direct aortic TAVI via anterior right mini-thoracotomy using 32 mm myval for pure aortic regurgitation

Background Aortic regurgitation with dilated annulus presents a technical challenge for conventional transcatheter aortic valve implantation (TAVI) procedures. Case presentation We report a case of an 84-year-old frail patient with a history of breathlessness found to have severe aortic regurgitation and moderately impaired left ventricular systolic function. The patient underwent a successful TAVI procedure using the XL-Myval 32 mm transcatheter heart valve (THV) via an anterior right mini-thoracotomy with a direct aortic approach. The patient recovered well post-operatively with good hemodynamic resolution. Conclusions This first in human case highlights the efficacy and potential of applying innovative approaches, such as the new sizes of Myval THV and direct aortic access via anterior right mini thoracotomy, in addressing challenging anatomical variations in TAVI procedures with good outcome. Supplementary Information The online version contains supplementary material available at 10.1186/s13019-024-02982-7.


Case presentation
An 84-year-old frail man was admitted electively for TAVI with symptomatic severe AR with NYHAIII symptoms.He is an ex-smoker with a history of COPD, symptomatic PVD, and awaiting urgent TEVAR for a large abdominal aortic aneurysm (AAA).Trans-thoracic echocardiography showed severe AR, dilated LVEDD (65 mm), and moderately impaired LV function (Video 1).Coronary angiogram showed non-obstructive coronary artery disease.
A cardiac CT showed a large aortic annulus (perimeter 90.5 mm, area 635mm 2 ) (Fig. 1) with no calcification and a saccular infrarenal aortic aneurysm measuring 52 mm.There may have been a previous contained rupture.He

Background
Transcatheter Aortic Valve Implantation (TAVI) has become a widely accepted intervention, particularly in aortic stenosis cases.However, its application in aortic regurgitation (AR) remains less common, presenting challenges, especially when dealing with a significantly enlarged aortic annuli.[1] This case report presents a significant milestone as the first documented case of inserting a size 32 mm MyVal THV for pure AR via anterior right mini-thoracotomy (ART), showing the feasibility and effectiveness of this was discussed by the HEART team and the consensus was for alternative access TAVI.
Under general anaesthesia without using CPB, a DA TAVI via 4 cm anterior right mini-thoracotomy (ART) in the 2nd ICS (Fig. 2) was performed.A bronchial blocker for isolated lung ventilation was used.The right internal mammary artery (RIMA) was clipped and divided.Using a soft tissue retractor, the pericardium was opened and traction sutures on the pericardium inserted.
Arterial/venous access via the right radial artery and right femoral vein for pigtail catheter and temporary pacing wire inserted respectively.Pigtail catheter advanced

Discussion
Innovations of transcatheter heart valves and relating delivery systems are continuously evolving.[2] Myval-XL THV (Meril Life Sciences Pvt. Ltd., India) is a balloon-expandable valve available in larger sizes, 30.5 and 32 mm, serving to treat patients with large annulus.[3] It can protect against valve embolisation and residual PVL in non-calcified aortic valves with dilated annulus and can be a good option for treatment of pure AR in high risk patients.[4] In instances where peripheral access is prohibitive, a trans-apical approach(through left anterior thoracotomy) or a direct aortic approach( performed through upper mini-sternotomy or anterior right mini-thoracotomy) can be considered.The ART access has been shown to reduce the risk of complications and recovery time compared to traditional surgical valve replacement.[5] In comparison to Trans-apical approach, ART is less invasive and associated with lower mortality and morbidity.[6] Additionally, using a soft tissue retractor and avoiding a rib spreader in ART results in less postoperative pain.Trans apical access was not suitable for this patient due to impaired LV function and the large size of the sheath required for the procedure.Compared to the upper ministernotomy approach, ART is less invasive and provides better alignment for valve implantation, although it demands a steeper learning curve for the surgeon.[7] This patient presented with significant comorbidities and frailty, compounded by symptomatic impaired left ventricular systolic function (LVSF) .Following heart team discussion, the patient was referred for TAVI assessment.With a diagnosis of pure aortic regurgitation (AR) and an annulus measuring (Area 635mm 2 , perimeter 90.5 mm), meticulous sizing was imperative to mitigate the risk of prosthesis embolisation and a size 32 mm Myval valve (nominal implant) was deemed appropriate to provide approximately 25% oversizing.While tansfemoral TAVI is the conventional licenced approach for this valve, the patient's history of a large saccular AAA necessitated an alternative approach.Consequently, a direct aortic approach via ART was preferred over TA access due to the larger sheath size required in addition to a moderately impaired LV.Precise guidance for the aortic puncture site under fluoroscopy was essential in addition to the pre-operative CT information.Additionally, device alignment was a critical consideration prompting the additional access site from above the ART access incision (above the 2nd rib).Following this, the TAVI procedure progressed smoothly.An effective strategy in achieving optimal valve positioning is to initially position the valve slightly deeper, facilitating subsequent adjustments upwards, rather than starting too high where re-adjustment becomes limited.In addition, DA approach allows for better proximal control of the device.

Conclusion
This case report demonstrates the successful use of the Myval transcatheter heart valve to treat pure aortic regurgitation with a large annulus.Using a direct ascending aorta approach via ART, along with thorough pre-procedural planning and intraoperative techniques, led to favourable outcome despite the patient's complex condition.The availability of larger valve sizes, like the size 32 mm Myval, was crucial in overcoming anatomical challenges.This emphasises the need for a tailored approach in patients with aortic valve disease and complex comorbidity.Further research and long-term follow-up are necessary to validate the effectiveness and durability of this approach.

Fig. 2 Fig. 1
Fig. 2 Direct aortic access site via the anterior right thoracotomy

Fig. 4 Fig. 3
Fig. 4 Final image of the wound appearance at the end of operation (Left) and on discharge(Right)